The disappearance of ultrasound contrast bubbles: Observations of bubble dissolution and cavitation nucleation

被引：107

作者：

Chen, WS ^{[1
]}

Matula, TJ ^{[1
]}

Crum, LA ^{[1
]}

机构：

[1] Univ Washington, Appl Phys Lab, Ctr Ind & Med Ultrasound, Seattle, WA 98105 USA

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2002年 / 28卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ultrasound; dissolution; cavitation; inertial cavitation; nucleation; ultrasound contrast agents; microbubbles;

D O I：

10.1016/S0301-5629(02)00517-3

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

The destruction process of biSphere(TM) and Optison(TM) ultrasound (US) contrast microbubbles were studied at 1.1 MHz. High-amplitude tone bursts caused shell disruption and/or fragmentation of the microbubbles, leading to dissolution of the freed gas. The bubble destruction and subsequent dissolution process was imaged with a high pulse-repetition frequency (PRF) 10-cycle, 5-MHz bistatic transducer configuration. Three types of dissolution profiles were measured: In one case, biSphere(TM) microbubbles showed evidence of dissolution through resonance, during which a temporary increase in the scattering amplitude was observed. In another case, both biSphere(TM) and Optison(TM) microbubbles showed evidence of fragmentation, during which the scattering amplitude decreased rapidly. Finally, in some cases, we observed the impulsive growth and subsequent rapid decay of signals that appear to be due to cavitation nucleation. Simulations of bubble dissolution curves show good agreement with experiments. (E-mail: matula@apl.washington.edu) (C) 2002 World Federation for Ultrasound in Medicine Biology.

引用

页码：793 / 803

页数：11

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