Fish are like flies are like frogs: Conservation of dorsal-ventral patterning mechanisms

被引：78

作者：

Holley, SA

Ferguson, EL

机构：

[1] Dept. Molec. Genet. and Cell Biol., University of Chicago, Chicago, IL 60637

来源：

BIOESSAYS | 1997年 / 19卷 / 04期

关键词：

D O I：

10.1002/bies.950190404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor-beta family member dpp patterns the embryonic dorsal-ventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp-4, the dpp homolog, in patterning the dorsal-ventral axis of chordates. A recent report has now identified mutations in two genes, dine and swirl, that disrupt dorsal-ventral patterning in the zebrafish Danio rerio((1)). Characterization of these mutations parallels findings from Drosophila, thus establishing a genetic framework for the analysis of dorsal-ventral patterning in a vertebrate.

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页码：281 / 284

页数：4

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