Vitamin D and its role in immunology: Multiple sclerosis, and inflammatory bowel disease

被引:209
作者
Cantorna, Margherita T. [1 ]
机构
[1] Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Immunol & Infect Dis, University Pk, PA 16802 USA
关键词
vitamin D and its role in immunology; multiple sclerosis; inflammatory bowel disease;
D O I
10.1016/j.pbiomolbio.2006.02.020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autoimmune diseases like multiple sclerosis (MS) and inflammatory bowel disease (IBD) occur because of an inappropriate immune-mediated attack against self-tissue. Analyses of genetically identical twins shows that besides genetics there are important environmental factors that contribute to MS and IBD development. Vitamin D availability due to sunshine exposure or diet may play a role in the development of MS and IBD. Compelling data in mice show that vitamin D and signaling through the vitamin D receptor dictate the outcome of experimental MS and IBD. Furthermore, the evidence points to the direct and indirect regulation of T cell development and function by vitamin D. In the absence of vitamin D and signals delivered through the vitamin D receptor, auto reactive T cells develop and in the presence of active vitamin D (1,25(OH)(2)D-3) and a functional vitamin D receptor the balance in the T cell response is restored and autoimmunity avoided. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:60 / 64
页数:5
相关论文
共 22 条
[1]   Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases [J].
Adorini, L ;
Penna, G ;
Giarratana, N ;
Uskokovic, M .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2003, 88 (02) :227-233
[2]   Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases [J].
Adorini, L .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2002, 2 (07) :1017-1028
[3]  
Andreassen H, 1998, SCAND J GASTROENTERO, V33, P1087
[4]   Inflammatory bowel disease and osteoporosis [J].
Andreassen, H ;
Rungby, J ;
Dahlerup, JF ;
Mosekilde, L .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1997, 32 (12) :1247-1255
[5]   SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN-D3 IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS - PRESENCE IN MONOCYTES AND INDUCTION IN LYMPHOCYTES-T FOLLOWING ACTIVATION [J].
BHALLA, AK ;
AMENTO, EP ;
CLEMENS, TL ;
HOLICK, MF ;
KRANE, SM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (06) :1308-1310
[6]   1,25-dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease [J].
Cantorna, MT ;
Munsick, C ;
Bemiss, C ;
Mahon, BD .
JOURNAL OF NUTRITION, 2000, 130 (11) :2648-2652
[7]  
Cantorna MT, 2004, AM J CLIN NUTR, V80, p1717S, DOI 10.1093/ajcn/80.6.1717S
[8]   Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence [J].
Cantorna, MT ;
Mahon, BD .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2004, 229 (11) :1136-1142
[9]   1,25-dihydroxyvitamin D-3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis [J].
Cantorna, MT ;
Hayes, CE ;
DeLuca, HF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7861-7864
[10]   1,25-dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis [J].
Cantorna, MT ;
Hayes, CE ;
DeLuca, HF .
JOURNAL OF NUTRITION, 1998, 128 (01) :68-72