Palladium-promoted cascade reactions of isonitriles and 6-iodo-N-propargylpyridones:: Synthesis of mappicines, camptothecins, and homocamptothecins

被引：99

作者：

Curran, DP ^{[1
]}

Du, W ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 19期

关键词：

D O I：

10.1021/ol026408d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ambient-temperature reactions of electron-rich aryl isonitriles with substituted 6-iodo-N-propargylpyridones in the presence of silver carbonate and palladium acetate produce 11H-indolizino[1,2b]quinolin-9-ones in good to excellent yield. Experimental evidence suggests that the process coccurs though organopalladium rather than radical intermediates. It is applied to synthesis analogues of mappicine and camptothecin, including the silatecans DB-67 and DB-91 (homo-DB-67).

引用

页码：3215 / 3218

页数：4

共 41 条

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