Carbon-carbon bond formation via the Mitsunobu reaction on solid supports

被引：11

作者：

Chaturvedi, S ^{[1
]}

Otteson, K ^{[1
]}

Bergot, J ^{[1
]}

机构：

[1] PE Biosyst, Organ Combinatorial Chem Grp, Foster City, CA 94404 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(99)01705-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The feasibility of C-C bond formation via the Mitsunobu reaction on solid supports has been investigated. Alkylation of a polymer supported alcohol with various compounds having an active methylene moiety in the presence of TMAD and Bu3P gave the desired monoalkylated product, as well as an unexpected bis-alkylated product in ratios depending on the substrate loading. A rationalization for the latter is also presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8205 / 8209

页数：5

共 15 条

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