Acid catalyzed rearrangement and acyl migration studies on 9-dihydro-13-acetylbaccatin-III, a major taxane from Taxus canadensis

被引：16

作者：

Zamir, LO

Balachandran, S

Zheng, YF

Nedea, ME

Caron, G

Nikolakakis, A

Vishwakarma, RA

Sauriol, F

Mamer, O

机构：

[1] NATL INST IMMUNOL,BIOORGAN CHEM LAB,NEW DELHI 110067,INDIA

[2] MCGILL UNIV,DEPT CHEM,MONTREAL,PQ H3A 2K6,CANADA

[3] MCGILL UNIV,BIOMED MASS SPECTROMETRY UNIT,MONTREAL,PQ H3A 1A3,CANADA

来源：

TETRAHEDRON | 1997年 / 53卷 / 47期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4020(97)10069-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A detailed investigation of the rearrangement of the major taxane from Taxus canadensis enables to suggest the sequence of the reactions involved: 9-dihydro-13-acetylbaccatin III - abeo-taxanes with intact oxetane and acyl migration - abeo-taxanes with intact oxetane and deacylation - abeo-taxanes with opening of the oxetane and various acyl migrations including two unusual benzoyl shifts. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：15991 / 16008

页数：18

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