Desmosomal adhesion: structural basis, molecular mechanism and regulation (Review)

被引：98

作者：

Garrod, DR ^{[1
]}

Merritt, AJ ^{[1
]}

Nie, ZX ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

MOLECULAR MEMBRANE BIOLOGY | 2002年 / 19卷 / 02期

关键词：

desmosome; cell adhesion; intercellular junction; epithelium; protein kinase C;

D O I：

10.1080/09687680210132476

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Desmosomes are adhesive intercellular junctions of epithelia and cardiac muscle. They have an essential function in maintaining the integrity of tissues, which is compromised in human genetic and autoimmune disease that targets desmosomal components. Recent evidence (1) suggests new roles for the function of desmosomal adhesion in tissue morphogenesis, (2) gives new insights into the molecular mechanism of adhesion, (3) indicates that the desmosomal adhesion molecules, desmocollin and desmoglein, may contribute to the regulation of epidermal diffentiation, and (4) shows that the affinity of desmosomal adhesion is regulated by protein kinase C.

引用

页码：81 / 94

页数：14

共 123 条

[21] A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris [J].

Caldelari, R ;

de Bruin, A ;

Baumann, D ;

Suter, MM ;

Bierkamp, C ;

Balmer, V ;

Müller, E .

JOURNAL OF CELL BIOLOGY, 2001, 153 (04) :823-834

[22] TISSUE-SPECIFIC AND STRATUM-SPECIFIC EXPRESSION OF THE HUMAN INVOLUCRIN PROMOTER IN TRANSGENIC MICE [J].

CARROLL, JM ;

ALBERS, KM ;

GARLICK, JA ;

HARRINGTON, R ;

TAICHMAN, LB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10270-10274

[23] Transgenic mice expression IFN-gamma in the epidermis have eczema, hair hypopigmentation, and hair loss [J].

Carroll, JM ;

Crompton, T ;

Seery, JP ;

Watt, FM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 108 (04) :412-422

[24] SUPRABASAL INTEGRIN EXPRESSION IN THE EPIDERMIS OF TRANSGENIC MICE RESULTS IN DEVELOPMENTAL DEFECTS AND A PHENOTYPE RESEMBLING PSORIASIS [J].

CARROLL, JM ;

ROMERO, MR ;

WATT, FM .

CELL, 1995, 83 (06) :957-968

[25] Multiple cadherin extracellular repeats mediate homophilic binding and adhesion [J].

Chappuis-Flament, S ;

Wong, E ;

Hicks, LD ;

Kay, CM ;

Gumbiner, BM .

JOURNAL OF CELL BIOLOGY, 2001, 154 (01) :231-243

[26] Plakoglobin suppresses epithelial proliferation and hair growth in vivo. [J].

Charpentier, E ;

Lavker, RM ;

Acquista, E ;

Cowin, P .

JOURNAL OF CELL BIOLOGY, 2000, 149 (02) :503-519

[27] Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation [J].

Chidgey, M ;

Brakebusch, C ;

Gustafsson, E ;

Cruchley, A ;

Hail, C ;

Kirk, S ;

Merritt, A ;

North, A ;

Tselepis, C ;

Hewitt, J ;

Byrne, C ;

Fassler, R ;

Garrod, D .

JOURNAL OF CELL BIOLOGY, 2001, 155 (05) :821-832

[28] Expression of full-length desmosomal glycoproteins (desmocollins) is not sufficient to confer strong adhesion on transfected L929 cells [J].

Chidgey, MAJ ;

Clarke, JP ;

Garrod, DR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (04) :689-695

[29] Direct Ca2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion [J].

Chitaev, NA ;

Troyanovsky, SM .

JOURNAL OF CELL BIOLOGY, 1997, 138 (01) :193-201

[30] CLONING AND SEQUENCE-ANALYSIS OF DESMOSOMAL GLYCOPROTEIN-2 AND GLYCOPROTEIN-3 (DESMOCOLLINS) - CADHERIN-LIKE DESMOSOMAL ADHESION MOLECULES WITH HETEROGENEOUS CYTOPLASMIC DOMAINS [J].

COLLINS, JE ;

LEGAN, PK ;

KENNY, TP ;

MACGARVIE, J ;

HOLTON, JL ;

GARROD, DR .

JOURNAL OF CELL BIOLOGY, 1991, 113 (02) :381-391

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