Navigating the network: signaling cross-talk in hematopoietic cells

被引：45

作者：

Fraser, Iain D. C. ^{[1
]}

Germain, Ronald N. ^{[2
,3
]}

机构：

[1] NIAID, Mol & Cell Biol Grp, NIH, Bethesda, MD 20892 USA

[2] NIAID, Immunol Grp, Program Syst Immunol & Infect Dis Modeling, NIH, Bethesda, MD 20892 USA

[3] NIAID, Lymphocyte Biol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 04期

基金：

美国国家卫生研究院;

关键词：

PROTEIN INTERACTION NETWORK; RNA-INTERFERENCE; SYSTEMS BIOLOGY; MULTIPLEXED ANALYSIS; FLUORESCENT PROTEIN; GENE-EXPRESSION; IN-VIVO; TRANSDUCTION; TYROSINE; KINASE;

D O I：

10.1038/ni.1711

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Recent studies in hematopoietic cells have led to a growing appreciation of the diverse modes of molecular and functional crosstalk between canonical signaling pathways. However, these intersections represent only the tip of the iceberg. Emerging global analytical methods are providing an even richer and more complete picture of the many components that measurably interact in a network manner to produce cellular responses. Here we highlight the pieces in this Focus, emphasize the limitations of the present canonical pathway paradigm, and discuss the value of a systems biology approach using more global, quantitative experimental design and data analysis strategies. Lastly, we urge caution about overly facile interpretation of genome-and proteome-level studies.

引用

页码：327 / 331

页数：5

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