Crystal structure of amikacin

被引：5

作者：

Bau, R ^{[1
]}

Tsyba, I ^{[1
]}

机构：

[1] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 52期

关键词：

antibiotics; amino sugars; glycosides; X-ray crystal structure;

D O I：

10.1016/S0040-4020(99)00983-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amikacin is one of the important aminoglycoside antibiotics used against gram-negative bacteria. Here we report the crystal structure of amikacin that has been crystallized by vapor diffusion against polyethylene glycol. The molecule exists in a long, extended conformation, with all three six-membered rings in chair conformations and connected together by alpha-glycosidic linkages. The orientation between the A, B and C rings of the molecule is maintained by intramolecular hydrogen bonds involving the O-5 hydroxyl group and the amide NH group. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：14839 / 14846

页数：8

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