Asymmetric synthesis of a new simplified dynemicin analogue equipped with a handle

被引：14

作者：

Banfi, L ^{[1
]}

Basso, A ^{[1
]}

Gandolfo, V ^{[1
]}

Guanti, G ^{[1
]}

Riva, R ^{[1
]}

机构：

[1] Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 22期

关键词：

enediynes; dynemicin; quinoline; Corey-Fuchs reaction;

D O I：

10.1016/j.tetlet.2004.04.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new simplified dynemicin analogue 16 was prepared enantio- and diastereoselectively in 17 steps starting from monoacetate (S) 7. It is equipped with a side arm containing a protected primary alcoholic function ('handle'), which can be used for conjugation with DNA-complexing agents or for devising new types of trigger. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：4221 / 4223

页数：3

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