Automated flow-through synthesis of heterocyclic thioethers

被引：25

作者：

Jönsson, D ^{[1
]}

Warrington, BH ^{[1
]}

Ladlow, M ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, GlaxoSmithKline Cambridge Technol Ctr, Cambridge CB2 1EW, England

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1021/cc0499486

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The fully automated, sequential flow-through synthesis of a 44-member array of thioethers 10{1-4, 1-11} employing a resin "capture and release" reactor column is described. The array incorporates four different heterocyclic scaffolds, and the synthesis was performed using a custom-built robotic synthesizer that is able to (i) load and regenerate the reactor column and (ii) array each product into a single vial using UV threshold detection. All the compounds were obtained in high yield (>75%) and excellent purity (>95%) without the need for further purification.

引用

页码：584 / 595

页数：12

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