Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents

被引：54

作者：

Caldarelli, M ^{[1
]}

Habermann, J ^{[1
]}

Ley, SV ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

amino acids and derivates; enzyme inhibitors; hydroxamic acids; solid phase synthesis;

D O I：

10.1016/S0960-894X(99)00311-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2049 / 2052

页数：4

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