An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles

被引：14

作者：

van den Hoogenband, Adri ^{[1
]}

Lange, Jos H. M. ^{[1
]}

Iwema-Bakker, Wouter I. ^{[1
]}

den Hartog, Jack A. J. ^{[1
]}

van Schaik, Jord ^{[1
]}

Feenstra, Rolf W. ^{[1
]}

Terpstra, Jan Willem ^{[1
]}

机构：

[1] Solvay Pharmaceut, Res Labs, NL-1381 CP Weesp, Netherlands

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 26期

关键词：

D O I：

10.1016/j.tetlet.2006.04.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with a (hetero)arylboronic acid in a one-pot reaction. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4361 / 4364

页数：4

共 25 条

[21] Speradine A, a new pentacyclic oxindole alkaloid from a marine-derived fungus Aspergillus tamarii
Tsuda, M
Mugishima, T
Komatsu, K
Sone, T
Tanaka, M
Mikami, Y
Shiro, M
Hirai, M
Ohizumi, Y
Kobayashi, J
[J]. TETRAHEDRON, 2003, 59 (18) : 3227 - 3230
[22] A novel synthesis of N-(piperidin-4-yl)-1,3-dihydroindol-2-one via an intramolecular Pd-catalyzed amination
van den Hoogenband, A
den Hartog, JAJ
Lange, JHM
Terpstra, JW
[J]. TETRAHEDRON LETTERS, 2004, 45 (46) : 8535 - 8537
[23] VANDENHOOGENBAN.A, UNPUB
[24] A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor
Zaveri, NT
Jiang, FM
Olsen, CM
Deschamps, JR
Parrish, D
Polgar, W
Toll, L
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (12) : 2973 - 2976
[25] Zhang XQ, 1996, MOL PHARMACOL, V49, P288

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