An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles

被引:14
作者
van den Hoogenband, Adri [1 ]
Lange, Jos H. M. [1 ]
Iwema-Bakker, Wouter I. [1 ]
den Hartog, Jack A. J. [1 ]
van Schaik, Jord [1 ]
Feenstra, Rolf W. [1 ]
Terpstra, Jan Willem [1 ]
机构
[1] Solvay Pharmaceut, Res Labs, NL-1381 CP Weesp, Netherlands
关键词
D O I
10.1016/j.tetlet.2006.04.103
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with a (hetero)arylboronic acid in a one-pot reaction. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4361 / 4364
页数:4
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