A novel synthesis of N-(piperidin-4-yl)-1,3-dihydroindol-2-one via an intramolecular Pd-catalyzed amination

被引：20

作者：

van den Hoogenband, A ^{[1
]}

den Hartog, JAJ ^{[1
]}

Lange, JHM ^{[1
]}

Terpstra, JW ^{[1
]}

机构：

[1] Solvay Pharmaceut, Res Labs, NL-1381 CP Weesp, Netherlands

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 46期

关键词：

D O I：

10.1016/j.tetlet.2004.09.121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel efficient synthetic route to the pharmaceutical key intermediate N-(piperidin-4-yl)-1,3-dihydroindol-2-one is described. The key step involves a high-yielding intramolecular palladium-catalyzed amination reaction using Buchwald's X-Phos ligand under mild reaction conditions. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8535 / 8537

页数：3

共 20 条

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