New perfluoroalkylated BINAP usable as a ligand in homogeneous and supercritical carbon dioxide asymmetric hydrogenation

被引：40

作者：

Berthod, M

Mignani, G

Lemaire, M

机构：

[1] UCBL, Lab Catalyse & Synth Organ, UMR 5181, F-69622 Villeurbanne, France

[2] Rhodia, Ctr Rech Lyon, F-69192 St Fons, France

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 07期

关键词：

D O I：

10.1016/j.tetasy.2004.02.004

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New (R)- or (S)-4,4'- and 5,5'-perfluoroalkylated BINAP have been synthesized in four steps from enantiomerically pure BINAP. These new ligands were used in the homogeneous asymmetric hydrogenation of ethyl acetoacetate in ethanol and in the asymmetric hydrogenation of methyl-2-acetamidoacrylate in supercritical carbon dioxide. In the supercritical media, the addition and nature of a co-solvent have been discussed. Very good conversion and selectivity were obtained in each case. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1121 / 1126

页数：6

共 19 条

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