The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

被引：255

作者：

Beld, Joris ^{[1
]}

Sonnenschein, Eva C. ^{[1
]}

Vickery, Christopher R. ^{[1
,2
]}

Noel, Joseph P. ^{[2
]}

Burkart, Michael D. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Jack H Skirball Ctr Chem Biol & Prote, Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 01期

基金：

美国国家科学基金会;

关键词：

ACYL-CARRIER-PROTEIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; BIOSYNTHETIC GENE-CLUSTER; FATTY-ACID SYNTHASE; ALPHA-AMINOADIPATE REDUCTASE; PUTATIVE 4'-PHOSPHOPANTETHEINYL TRANSFERASE; PRODRUG ACTIVATION MECHANISM; DIRECTED MUTATIONAL ANALYSIS; COMPLETE GENOME SEQUENCE; ESCHERICHIA-COLI K-12;

D O I：

10.1039/c3np70054b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et at. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. In the past two decades an increasing number of papers have been published on PPTases ranging from identification, characterization, structure determination, mutagenesis, inhibition, and engineering in synthetic biology. In this review, we comprehensively discuss all current knowledge on this class of enzymes that post-translationally install a 4'-phosphopantetheine arm on various carrier proteins.

引用

页码：61 / 108

页数：48

共 374 条

[31] Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum [J].

Cai, XM ;

Herschap, D ;

Zhu, G .

EUKARYOTIC CELL, 2005, 4 (07) :1211-1220

[32] The role of HetN in maintenance of the heterocyst pattern in Anabaena sp PCC 7120 [J].

Callahan, SM ;

Buikema, WJ .

MOLECULAR MICROBIOLOGY, 2001, 40 (04) :941-950

[33] A polyketide-synthase-like gene is involved in the synthesis of heterocyst glycolipids in Nostoc punctiforme strain ATCC 29133 [J].

Campbell, EL ;

Cohen, MF ;

Meeks, JC .

ARCHIVES OF MICROBIOLOGY, 1997, 167 (04) :251-258

[34] Mining microbial genomes for new natural products and biosynthetic pathways [J].

Challis, Gregory L. .

MICROBIOLOGY-SGM, 2008, 154 :1555-1569

[35] The nonredundant roles of two 4′-phosphopantetheinyl transferases in vital processes of Mycobacteria [J].

Chalut, C ;

Botella, L ;

de Sousa-D'Auria, C ;

Houssin, C ;

Guilhot, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (22) :8511-8516

[36]

Chalut C., 2007, [No title captured], Patent No. [EP1795608, 1795608]

[37] Selective Enrichment of Environmental DNA Libraries for Genes Encoding Nonribosomal Peptides and Polyketides by Phosphopantetheine Transferase-Dependent Complementation of Siderophore Biosynthesis [J].

Charlop-Powers, Zachary ;

Banik, Jacob J. ;

Owen, Jeremy G. ;

Craig, Jeffrey W. ;

Brady, Sean F. .

ACS CHEMICAL BIOLOGY, 2013, 8 (01) :138-143

[38] In Vitro Kinetic Analysis of Substrate Specificity in Enterobactin Biosynthetic Lower Pathway Enzymes Provides Insight into the Biochemical Function of the Hot Dog-Fold Thioesterase EntH [J].

Chen, Danqi ;

Wu, Rui ;

Bryan, Tyre L. ;

Dunaway-Mariano, Debra .

BIOCHEMISTRY, 2009, 48 (03) :511-513

[39] Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase:: an essential enzyme in bacterial fatty acid biosynthesis [J].

Chirgadze, NY ;

Briggs, SL ;

McAllister, KA ;

Fischl, AS ;

Zhao, GS .

EMBO JOURNAL, 2000, 19 (20) :5281-5287

[40] Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism [J].

Chu, M ;

Mierzwa, R ;

Xu, L ;

Yang, SW ;

He, L ;

Patel, M ;

Stafford, J ;

Macinga, D ;

Black, T ;

Chan, TM ;

Gullo, V .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (21) :3827-3829

← 1 2 3 4 5 6 7 8 9 10 →