ent-kaurane diterpenoids from the leaves of Isodon xerophilus

被引：19

作者：

Li, SH

Niu, XM

Peng, LY

Zhang, HJ

Yao, P

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL USA

来源：

PLANTA MEDICA | 2002年 / 68卷 / 10期

关键词：

D O I：

10.1055/s-2002-34926

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1-3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC50 = 0.09 and 0.32 mug/ml, respectively.

引用

页码：946 / 948

页数：3

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