Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea

被引：114

作者：

Park, Wan Beom ^{[1
]}

Perera, Ranawaka A. P. M. ^{[2
]}

Choe, Pyoeng Gyun ^{[1
]}

Lau, Eric H. Y. ^{[2
]}

Choi, Seong Jin ^{[1
]}

Chun, June Young ^{[1
]}

Oh, Hong Sang ^{[1
]}

Song, Kyoung-Ho ^{[1
]}

Bang, Ji Hwan ^{[1
]}

Kim, Eu Suk ^{[1
]}

Kim, Hong Bin ^{[1
]}

Park, Sang Won ^{[1
]}

Kim, Nam Joong ^{[1
]}

Poon, Leo Lit Man ^{[2
]}

Peiris, Malik ^{[3
]}

Oh, Myoung-don ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Seoul 110799, South Korea

[2] Univ Hong Kong, Pokfulam, Hong Kong, Peoples R China

[3] Univ Hong Kong, Pasteur Res Pole, Pokfulam, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.3201/eid2112.151421

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease.

引用

页码：2186 / 2189

页数：4

共 10 条

[1] Disappearance of antibodies to SARS-associated coronavirus after recovery [J].

Cao, Wu-Chun ;

Liu, Wei ;

Zhang, Pan-He ;

Zhang, Fang ;

Richardus, Jan H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (11) :1162-1163

[2] Transmission of MERS-Coronavirus in Household Contacts [J].

Drosten, Christian ;

Meyer, Benjamin ;

Mueller, Marcel A. ;

Corman, Victor M. ;

Al-Masri, Malak ;

Hossain, Raheela ;

Madani, Hosam ;

Sieberg, Andrea ;

Bosch, Berend Jan ;

Lattwein, Erik ;

Alhakeem, Raafat F. ;

Assiri, Abdullah M. ;

Hajomar, Waleed ;

Albarrak, Ali M. ;

Al-Tawfiq, Jaffar A. ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (09) :828-835

[3] Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity [J].

Hemida, M. G. ;

Perera, R. A. ;

Al Jassim, R. A. ;

Kayali, G. ;

Siu, L. Y. ;

Wang, P. ;

Chu, K. W. ;

Perlman, S. ;

Ali, M. A. ;

Alnaeem, A. ;

Guan, Y. ;

Poon, L. L. ;

Saif, L. ;

Peiris, M. .

EUROSURVEILLANCE, 2014, 19 (23) :2-7

[4] Neutralizing antibody response and SARS severity [J].

Ho, MS ;

Chen, WJ ;

Chen, HY ;

Lin, SF ;

Wang, MC ;

Di, JL ;

Lu, YT ;

Liu, CL ;

Chang, SC ;

Chao, CL ;

King, CC ;

Chiou, JM ;

Su, IJ ;

Yang, JY .

EMERGING INFECTIOUS DISEASES, 2005, 11 (11) :1730-1737

[5] Serological assays for emerging coronaviruses: Challenges and pitfalls [J].

Meyer, Benjamin ;

Drosten, Christian ;

Mueller, Marcel A. .

VIRUS RESEARCH, 2014, 194 :175-183

[6]

Muth D, 2015, J CLIN MICROBIOL

[7]

WHO, 2019, Disease Outbreak News

[8]

Wicklin R, 2015, JITTERING PREVENT OV

[9]

Yang JS, 2015, EMERG INFECT DIS

[10] Kinetics of serological responses in influenza A(H7N9)-infected patients correlate with clinical outcome in China, 2013 [J].

Zhang, A. ;

Huang, Y. ;

Tian, D. ;

Lau, E. H. ;

Wan, Y. ;

Liu, X. ;

Dong, Y. ;

Song, Z. ;

Zhang, X. ;

Zhang, J. ;

Bao, M. ;

Zhou, M. ;

Yuan, S. ;

Sun, J. ;

Zhu, Z. ;

Hu, Y. ;

Chen, L. ;

Leung, C. Y. ;

Wu, J. T. ;

Zhang, Z. ;

Zhang, Xiaoyan ;

Peiris, J. S. ;

Xu, J. .

EUROSURVEILLANCE, 2013, 18 (50) :38-45

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