Synthesis of 1,2,4-triazole-functionalized solid support and its use in the solid-phase synthesis of trisubstituted 1,2,4-triazoles

被引：44

作者：

Katritzky, AR ^{[1
]}

Qi, M

Feng, DM

Zhang, GF

Griffith, MC

Watson, K

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Trega Biosci Inc, San Diego, CA 92121 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 08期

关键词：

D O I：

10.1021/ol990186a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] 1,2,4-Triazoles were synthesized on a solid support in three steps, with excellent yields and purities. The utility of this triazole-functionalized solid support was demonstrated by the solid-phase synthesis of various trisubstituted 1,2,4 triazoles.

引用

页码：1189 / 1191

页数：3

共 30 条

[1] CARBON-CARBON BOND-FORMING METHODS ON SOLID SUPPORT - UTILIZATION OF KENNER SAFETY-CATCH LINKER [J].

BACKES, BJ ;

ELLMAN, JA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (24) :11171-11172

[2]

Balkenhohl F, 1996, ANGEW CHEM INT EDIT, V35, P2289

[3]

CHENERA B, 1995, J AM CHEM SOC, V117, P11999

[4]

CZARNIK AW, 1996, ACCOUNTS CHEM RES, V29, P111

[5] A CONVENIENT SYNTHESIS OF 3,5-DISUBSTITUTED-1,2,4-TRIAZOLES [J].

FRANCIS, JE ;

GORCZYCA, LA ;

MAZZENGA, GC ;

MECKLER, H .

TETRAHEDRON LETTERS, 1987, 28 (43) :5133-5136

[6] Traceless linker: Oxidative activation and displacement of a sulfur-based linker [J].

Gayo, LM ;

Suto, MJ .

TETRAHEDRON LETTERS, 1997, 38 (02) :211-214

[7] Solid-phase organic reactions .2. A review of the literature Nov 95 Nov 96. [J].

Hermkens, PHH ;

Ottenheijm, HCJ ;

Rees, DC .

TETRAHEDRON, 1997, 53 (16) :5643-5678

[8]

HOUGHTEN R, 1986, Patent No. 4631211

[9]

HUGHES DL, 1992, ORG REACTIONS, V42, P355

[10] ISOMERIZATIONS OF N-(ALPHA-AMINOALKYL)-1,2,4-TRIAZOLES AND N-(ALPHA-AMINOALKYL)TETRAZOLES [J].

KATRITZKY, AR ;

JOZWIAK, A ;

LUE, P ;

YANNAKOPOULOU, K ;

PALENIK, GJ ;

ZHANG, ZY .

TETRAHEDRON, 1990, 46 (02) :633-640

← 1 2 3 →