Esmodil:: An acetylcholine mimetic resurfaces in a southern australian marine sponge Raspailia (Raspailia) sp.

被引：23

作者：

Capon, RJ ^{[1
]}

Skene, C

Liu, EH

Lacey, E

Gill, JH

Heiland, K

Friedel, T

机构：

[1] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[2] Microbial Screening Technol, Kemps Creek, NSW 2171, Australia

[3] Novartis Anim Hlth Australasia Pty Ltd, Kemps Creek, NSW 2171, Australia

来源：

NATURAL PRODUCT RESEARCH | 2004年 / 18卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

esmodil; Raspailia (Raspailia) sp; nematocides;

D O I：

10.1080/14786410310001620619

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Bioassay directed fractionation of a Raspailia (Raspailia) sp. (Order Poecilosclerida; Family Raspailiidae) collected during scientific trawling operations off the Northern Rottnest Shelf yielded as nematocidal agents the known metabolites, phorboxazoles A (1) and B (2). Further examination revealed the new natural product but known synthetic compound, esmodil (3). The structure for 3 was confirmed by spectroscopic analysis and total synthesis.

引用

页码：305 / 309

页数：5

共 16 条

[1]

BROWN G, 1938, MED J AUSTRALIA, V2, P863

[2] Geodin A magnesium salt:: A novel nematocide from a southern Australian marine sponge, Geodia [J].

Capon, RJ ;

Skene, C ;

Lacey, E ;

Gill, JH ;

Wadsworth, D ;

Friedel, T .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (09) :1256-1259

[3] Phoriospongin A and B:: Two new nematocidal depsipeptides from the Australian marine sponges Phoriospongia sp and Callyspongia bilamellata [J].

Capon, RJ ;

Ford, J ;

Lacey, E ;

Gill, JH ;

Heiland, K ;

Friedel, T .

JOURNAL OF NATURAL PRODUCTS, 2002, 65 (03) :358-363

[4] The isolation and synthesis of novel nematocidal dithiocyanates from an Australian marine sponge, Oceanapia sp. [J].

Capon, RJ ;

Skene, C ;

Liu, EHT ;

Lacey, E ;

Gill, JH ;

Heiland, K ;

Friedel, T .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (23) :7765-7769

[5] Marine nematocides:: Tetrahydrofurans from a southern Australian brown alga, Notheia anomala. [J].

Capon, RJ ;

Barrow, RA ;

Rochfort, S ;

Jobling, M ;

Skene, C ;

Lacey, E ;

Gill, JH ;

Friedel, T ;

Wadsworth, D .

TETRAHEDRON, 1998, 54 (10) :2227-2242

[6]

HECHT G, 1935, KLIN WOCHENSCHR, V14, P957

[7]

IZAKI NORIYUKI, 1941, JAP JOUR MED SCI IV PHARMACOL, V13, P127

[8]

IZAKI NORIYUKI, 1940, FOLIA PHARMACOL JAP, V29, P49

[9] Absolute configuration of phorboxazole A C32-C43 analogs by CD exciton-coupling of allylic 2-naphthoate esters [J].

Molinski, TF ;

Brzezinski, LJ ;

Leahy, JW .

TETRAHEDRON-ASYMMETRY, 2002, 13 (10) :1013-1016

[10]

MORATSCHEK J, 1944, ARCH EXP PATHOL PH, V203, P278

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