Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study

被引：24

作者：

Busby, John ^{[1
]}

Holweg, Cecile T. J. ^{[2
]}

Chai, Akiko ^{[2
]}

Bradding, Peter ^{[3
]}

Cai, Fang ^{[2
]}

Chaudhuri, Rekha ^{[4
,5
]}

Mansur, Adel H. ^{[6
]}

Lordan, James Laurence ^{[7
]}

Matthews, John G. ^{[8
]}

Menzies-Gow, Andrew ^{[9
]}

Niven, Robert ^{[10
]}

Staton, Tracy ^{[2
]}

Heaney, Liam G. ^{[11
]}

机构：

[1] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Expt Med, Belfast, Antrim, North Ireland

[2] Genentech Inc, Roche Grp, San Francisco, CA USA

[3] Univ Leicester, Dept Infect Immun & Inflammat, Inst Lung Hlth, Leicester, Leics, England

[4] Gartnavel Royal Hosp, Resp Med, Glasgow, Lanark, Scotland

[5] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland

[6] Heartlands Hosp, Resp, Birmingham, W Midlands, England

[7] Freeman Rd Hosp, Resp, Newcastle Upon Tyne, Tyne & Wear, England

[8] Genentech Inc, Roche Grp, Prod Dev, San Francisco, CA USA

[9] Royal Brompton Hosp, London, England

[10] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England

[11] Queens Univ Belfast, Ctr Infect & Immun, Belfast, Antrim, North Ireland

来源：

THORAX | 2019年 / 74卷 / 08期

基金：

英国医学研究理事会;

关键词：

INFLAMMATION; PREDICTORS; EXPRESSION;

D O I：

10.1136/thoraxjnl-2018-212709

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Type-2 biomarkers and related cytokines (IL-5, IL-13), lung function and asthma symptoms were measured in 44 poorly-controlled severe oral corticosteroid (OCS)-dependent asthmatics for up to 88 days after a 7-day prednisolone boost (0.5 mg/kg). High-dose OCS reduced median blood eosinophils (-60 cells/mu l; 95% CI - 140 to 10), periostin (-8.4 ng/mL; -11.6 to -2.8), FeNO (-19.0 ppb; -28.5 to -4.0), IL-5 (-0.17 pg/mL; -0.28 to -0.08) and IL-13 (-0.15 pg/mL; -0.27 to -0.03). There were small improvements in mean FEV 1 (0.16 L; 0.05 to 0.27) and (Asthma Control Questionnaire) ACQ-7 score (0.3; 0.0 to 0.7). Study measures returned to baseline 1-month postintervention. Following rescue OCS, 1 month is sufficient before using type-2 biomarkers to guide long-term treatment.

引用

页码：806 / 809

页数：4

共 10 条

[1]

Prednisolone treatment in asthma - Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa [J].