A highly efficient microwave-assisted solvent-free synthesis of α- and β-2′-deoxy-1,2,3-triazolyl-nucleosides

被引：79

作者：

Guezguez, Raja

Bougrin, Khalid

El Akri, Khalid

Benhida, Rachid

机构：

[1] Univ Nice, CNRS, UMR 6001, Chim Bioorgan Lab, F-06108 Nice 2, France

[2] Univ Mohammed V Agdal, Fac Sci, Lab Chim Plantes & Synth Organ & Bioorgan, Rabat, Morocco

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 28期

关键词：

D O I：

10.1016/j.tetlet.2006.05.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Microwave activation coupled with Cu(I) catalysis, under solvent-free conditions, was found to dramatically enhance the 1,3-dipolar cycloaddition between azido-2'-deoxyribose and terminal alkynes. The process is highly efficient and quantitatively affords, in few minutes, the corresponding 4-substituted 1,2,3-triazolyl-nucleosides. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4807 / 4811

页数：5

共 28 条

[1]

[Anonymous], CHEM NUCLEOSIDES NUC

[2]

A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction [J].