Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

被引：700

作者：

Schito, Luana ^{[1
]}

Semenza, Gregg L. ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Johns Hopkins Univ, Sch Med, Inst Cell Engn, McKusick Nathans Inst Genet Med, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21218 USA

[7] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

TRENDS IN CANCER | 2016年 / 2卷 / 12期

关键词：

oxygen biology; tumor microenvironment;

D O I：

10.1016/j.trecan.2016.10.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intratumoral hypoxia (reduced O-2 availability) is a common finding in human cancer and leads to increased activity of hypoxia-inducible factors (HIFs), which regulate the expression of genes that contribute to angiogenesis, metabolic reprogramming, extracellular matrix remodeling, epithelial-mesenchymal transition, motility, invasion, metastasis, cancer stem cell maintenance, immune evasion, and resistance to chemotherapy and radiation therapy. Conventional anticancer therapies target well-oxygenated and proliferating cancer cells, whereas there are no approved therapies that target hypoxic cancer cells, despite growing clinical and experimental evidence indicating that intratumoral hypoxia is a critical microenvironmental factor driving cancer progression. In this review, our current understanding of the consequences of HIF activity and the translational potential of targeting HIFs for cancer therapy are discussed.

引用

页码：758 / 770

页数：13

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