Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

被引：700

作者：

Schito, Luana ^{[1
]}

Semenza, Gregg L. ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Johns Hopkins Univ, Sch Med, Inst Cell Engn, McKusick Nathans Inst Genet Med, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21218 USA

[7] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

TRENDS IN CANCER | 2016年 / 2卷 / 12期

关键词：

oxygen biology; tumor microenvironment;

D O I：

10.1016/j.trecan.2016.10.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intratumoral hypoxia (reduced O-2 availability) is a common finding in human cancer and leads to increased activity of hypoxia-inducible factors (HIFs), which regulate the expression of genes that contribute to angiogenesis, metabolic reprogramming, extracellular matrix remodeling, epithelial-mesenchymal transition, motility, invasion, metastasis, cancer stem cell maintenance, immune evasion, and resistance to chemotherapy and radiation therapy. Conventional anticancer therapies target well-oxygenated and proliferating cancer cells, whereas there are no approved therapies that target hypoxic cancer cells, despite growing clinical and experimental evidence indicating that intratumoral hypoxia is a critical microenvironmental factor driving cancer progression. In this review, our current understanding of the consequences of HIF activity and the translational potential of targeting HIFs for cancer therapy are discussed.

引用

页码：758 / 770

页数：13

共 90 条

[41] Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
Koivunen, Peppi
Lee, Sungwoo
Duncan, Christopher G.
Lopez, Giselle
Lu, Gang
Ramkissoon, Shakti
Losman, Julie A.
Joensuu, Paivi
Bergmann, Ulrich
Gross, Stefan
Travins, Jeremy
Weiss, Samuel
Looper, Ryan
Ligon, Keith L.
Verhaak, Roel G. W.
Yan, Hai
Kaelin, William G., Jr.
[J]. NATURE, 2012, 483 (7390) : 485 - U144
[42] The ever-expanding role of HIF in tumour and stromal biology
LaGory, Edward L.
Giaccia, Amato J.
[J]. NATURE CELL BIOLOGY, 2016, 18 (04) : 356 - 365
[43] Molecular mechanisms of epithelial-mesenchymal transition
Lamouille, Samy
Xu, Jian
Derynck, Rik
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (03) : 178 - 196
[44] RETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization (Retracted Article)
Lee, KangAe
Zhang, Huafeng
Qian, David Z.
Rey, Sergio
Liu, Jun O.
Semenza, Gregg L.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (42) : 17910 - 17915
[45] RETRACTED: Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells (Retracted article. See vol. 119, 2022)
Lee, KangAe
Qian, David Z.
Rey, Sergio
Wei, Hong
Liu, Jun O.
Semenza, Gregg L.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) : 2353 - 2358
[46] Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
Lu, Haiquan
Samanta, Debangshu
Xiang, Lisha
Zhang, Huimin
Hu, Hongxia
Chen, Ivan
Bullen, John W.
Semenza, Gregg L.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (33) : E4600 - E4609
[47] Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Luo, Weibo
Hu, Hongxia
Chang, Ryan
Zhong, Jun
Knabel, Matthew
O'Meally, Robert
Cole, Robert N.
Pandey, Akhilesh
Semenza, Gregg L.
[J]. CELL, 2011, 145 (05) : 732 - 744
[48] Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
Ma, Biao
Chen, Yan
Chen, Ling
Cheng, Hongcheng
Mu, Chenglong
Li, Jie
Gao, Ruize
Zhou, Changqian
Cao, Lei
Liu, Jinhua
Zhu, Yushan
Chen, Quan
Wu, Shian
[J]. NATURE CELL BIOLOGY, 2015, 17 (01) : 95 - +
[49] HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells
Mathieu, Julie
Zhang, Zhan
Zhou, Wenyu
Wang, Amy J.
Heddleston, John M.
Pinna, Claudia M. A.
Hubaud, Alexis
Stadler, Bradford
Choi, Michael
Bar, Merav
Tewari, Muneesh
Liu, Alvin
Vessella, Robert
Rostomily, Robert
Born, Donald
Horwitz, Marshall
Ware, Carol
Blau, C. Anthony
Cleary, Michele A.
Rich, Jeremy N.
Ruohola-Baker, Hannele
[J]. CANCER RESEARCH, 2011, 71 (13) : 4640 - 4652
[50] Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, Christian M.
Gameiro, Paulo A.
Bell, Eric L.
Mattaini, Katherine R.
Yang, Juanjuan
Hiller, Karsten
Jewell, Christopher M.
Johnson, Zachary R.
Irvine, Darrell J.
Guarente, Leonard
Kelleher, Joanne K.
Vander Heiden, Matthew G.
Iliopoulos, Othon
Stephanopoulos, Gregory
[J]. NATURE, 2012, 481 (7381) : 380 - U166

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