New perspectives on connecting messenger RNA 3' end formation to transcription

被引：233

作者：

Proudfoot, N ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 03期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.ceb.2004.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances in understanding the molecular mechanism of mRNA 3' end cleavage and polyadenylation have uncovered an unanticipated involvement of this process in the regulation of the transcriptional apparatus on its chromatin template. Thus, newly defined factors associated with mRNA 3' end formation are also connected with initiation of transcription, suggesting a close collaboration between the initiation and termination phases of transcription. Furthermore several of these factors are involved in setting up appropriate chromatin structure to facilitate efficient transcriptional elongation and termination.

引用

页码：272 / 278

页数：7

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