High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain

被引：280

作者：

Nasiriavanaki, Mohammadreza ^{[1
]}

Xia, Jun ^{[1
]}

Wan, Hanlin ^{[1
]}

Bauer, Adam Quentin ^{[2
]}

Culver, Joseph P. ^{[2
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, Opt Imaging Lab, St Louis, MO 63130 USA

[2] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 01期

基金：

美国国家卫生研究院;

关键词：

fcPAT; RSFC; mouse brain functional imaging; hyperoxia; hypoxia; DEFAULT NETWORK; GENE-EXPRESSION; GLOBAL SIGNAL; BOLD SIGNAL; FLUCTUATIONS; FMRI; LEVEL; MICROSCOPY; CORTEX; TASK;

D O I：

10.1073/pnas.1311868111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The increasing use of mouse models for human brain disease studies presents an emerging need for a new functional imaging modality. Using optical excitation and acoustic detection, we developed a functional connectivity photoacoustic tomography system, which allows noninvasive imaging of resting-state functional connectivity in the mouse brain, with a large field of view and a high spatial resolution. Bilateral correlations were observed in eight functional regions, including the olfactory bulb, limbic, parietal, somatosensory, retrosplenial, visual, motor, and temporal regions, as well as in several subregions. The borders and locations of these regions agreed well with the Paxinos mouse brain atlas. By subjecting the mouse to alternating hyperoxic and hypoxic conditions, strong and weak functional connectivities were observed, respectively. In addition to connectivity images, vascular images were simultaneously acquired. These studies show that functional connectivity photoacoustic tomography is a promising, noninvasive technique for functional imaging of the mouse brain.

引用

页码：21 / 26

页数：6

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