6-Chloro-2(2H)-pyranone:: a new 2(2H)-pyranone synthon

被引：26

作者：

Biagetti, M ^{[1
]}

Bellina, F ^{[1
]}

Carpita, A ^{[1
]}

Rossi, R ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 03期

关键词：

pyrones; Sonogashira reaction; palladium catalysis; selectivity; hydrogenation;

D O I：

10.1016/S0040-4039(02)02600-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-Chloro-2(2H)-pyranone, which can be prepared in high yield from commercially available trans -glutaconic acid, undergoes facile Pd/Cu-catalyzed reaction with various 1-alkynes to give rise to the corresponding 6-(1-alkynyl)-2(2H)-pyranones in moderate to good yields. These last hitherto unknown compounds have been used as direct precursors to 6-alkyl- and 6-[(Z)-1-alkenyl]-2(2H)-pyranones. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：607 / 610

页数：4

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