Direct ortho iodination of β- and γ-aryl alkylamine derivatives

被引：34

作者：

Barluenga, Jose

Alvarez-Gutierrez, Julia M.

Ballesteros, Alfredo

Gonzalez, Jose M.

机构：

[1] Univ Oviedo, CSIC, Inst Univ Quim Organomet Enrique Moles, Unidad Asociada, E-33006 Oviedo, Spain

[2] Univ Burgos, Dept Quim, Area Quim Organ, Fac Ciencias, Burgos 09001, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 08期

关键词：

amino acids; cross-coupling; electrophilic aromatic substitution; iodine; neighboring-group effects;

D O I：

10.1002/anie.200603631

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two in one! A trifluoroacetamide protecting group not only masks an amine functionality, but also mimics peptidyl directing effects as a controlling unit in an efficient ortho iodination of a variety of biologically relevant small molecules (see example). (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：1281 / 1283

页数：3

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