p53 phosphorylation: Biochemical and functional consequences

被引：81

作者：

Milczarek, GJ ^{[1
]}

Martinez, J ^{[1
]}

Bowden, GT ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT MOL & CELLULAR BIOL,TUCSON,AZ 85721

来源：

LIFE SCIENCES | 1996年 / 60卷 / 01期

关键词：

p53; phosphorylation; cellular function; protein kinases; protein phosphatases;

D O I：

10.1016/S0024-3205(96)00479-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The p53 protein plays a vital role in suppressing the development of cancer. Posttranslational modification through phosphorylation has been postulated to be an important regulatory mechanism of p53 function. Data describing the role of phosphorylation in terms of its effects on several biochemical properties and cellular functions of p53 are examined in the context of how p53 might be ''phospho-regulated.''

引用

页码：1 / 11

页数：11

共 75 条

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