Cyclisation of aminyl radicals derived from amino acids

被引：33

作者：

Bowman, WR ^{[1
]}

Broadhurst, MJ ^{[1
]}

Coghlan, DR ^{[1
]}

Lewis, KA ^{[1
]}

机构：

[1] ROCHE PROD LTD,DISCOVERY,WELWYN GARDEN CIT AL7 3AY,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 35期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(97)01413-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Amino acid aminyl radicals have been generated from sulfenamide precursors using Bu3SnH. The aminyl radicals undergo 5-exo-trig cyclisation reactions onto suitably placed N-alkenyl or alpha-alkenyl chains on the amino acids with reasonable diastereoselectivity. The alpha-ester of the amino acid imparts electrophilic behaviour to the aminyl radicals and facilitates cyclisation onto alkenes. (C) 1997 Elsevier Science Ltd.

引用

页码：6301 / 6304

页数：4

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