Lack of association between hypermutation and antibiotic resistance development in Pseudomonas aeruginosa isolates from intensive care unit patients

被引:53
作者
Gutiérrez, O [1 ]
Juan, C [1 ]
Pérez, JL [1 ]
Oliver, A [1 ]
机构
[1] Hosp Son Dureta, Microbiol Serv, Palma de Mallorca 07014, Spain
关键词
D O I
10.1128/AAC.48.9.3573-3575.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational antibiotic resistance development is a frequent outcome, the prevalence of hypermutable strains is low (found in isolates from only 1 of 103 patients) and there is no evidence of coselection of the hypermutable and antibiotic resistance phenotypes.
引用
收藏
页码:3573 / 3575
页数:3
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