On the acceptor substrate of C-glycosyl-transferase UrdGT2:: Three prejadomycin C-glycosides from an engineered mutant of Streptomyces globisporus 1912 ΔlndE(urdGT2)

被引：33

作者：

Baig, Irfan

Kharel, Madan

Kobylyanskyy, Anton

Zhu, Lili

Rebets, Yuriy

Ostash, Bohdan

Luzhetskyy, Andriy

Bechthold, Andreas

Fedorenko, Victor A.

Rohr, Juergen

机构：

[1] Lviv Natl Univ, Dept Biochem & Genet, UA-79005 Lvov, Ukraine

[2] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA

[3] Univ Freiburg, D-79104 Freiburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 46期

关键词：

D O I：

10.1002/anie.200603176

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The transfer of the gene urdGT2, which encodes a C-glycosyltransferase in the urdamycin pathway, into the lnd-minus mutant of the landomycin (lnd) biosynthetic pathway indicates the difference in the first glycosylation step in the urdamycin and landomycin pathways. It also reveals indirectly the acceptor substrate of UrdGT2 (see scheme) and gives evidence of greatly relaxed substrate specificity of all lnd glycosyltransferases except LndGT2. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：7842 / 7846

页数：5

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