Beyond D-luciferin: expanding the scope of bioluminescence imaging in vivo

被引：110

作者：

Adams, Spencer T., Jr. ^{[1
]}

Miller, Stephen C. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2014年 / 21卷

基金：

美国国家卫生研究院;

关键词：

FIREFLY LUCIFERASE; RENILLA LUCIFERASE; HYDROGEN-PEROXIDE; CASPASE ACTIVITY; REPORTER GENES; MURINE MODEL; ENZYME; RED; SUBSTRATE; ANALOGS;

D O I：

10.1016/j.cbpa.2014.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The light-emitting chemical reaction catalyzed by the enzyme firefly luciferase is widely used for noninvasive imaging in live mice. However, photon emission from the luciferase is crucially dependent on the chemical properties of its substrate, D-luciferin. In this review, we describe recent work to replace the natural luciferase substrate with synthetic analogs that extend the scope of bioluminescence imaging.

引用

页码：112 / 120

页数：9

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