Synthesis of novel and non-natural ceramide analogues derived from L-glutamic acid

被引：15

作者：

Shikata, K ^{[1
]}

Azuma, H ^{[1
]}

Tachibana, T ^{[1
]}

Ogino, K ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Engn, Dept Bioappl Chem, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

TETRAHEDRON | 2002年 / 58卷 / 29期

关键词：

ceramide; glutamic acid; sphingolipids;

D O I：

10.1016/S0040-4020(02)00558-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel and non-natural ceramide analogues, having a different methylene spacer between the primary hydroxymethyl group and aminomethane of sphingosine backbone, have been prepared from L-glutamic acid. The key step in the preparation is the diastereoselective reduction of an enone adjacent to a Boc protected amino group by reducing agents. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5803 / 5809

页数：7

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