ortho-arylation of benzamides

被引：108

作者：

Shabashov, Dmitry ^{[1
]}

Daugulis, Olafs ^{[1
]}

机构：

[1] Univ Houston, Dept Chem, Houston, TX 77204 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 21期

关键词：

D O I：

10.1021/ol0619866

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple method for the direct ortho-arylation of benzoic acid amides has been developed. The palladium-catalyzed reactions proceed in trifluoroacetic acid and require the presence of stoichiometric silver acetate. This presents an alternative to the currently used ortho-lithiation strategies for the synthesis of arylated benzoic acid derivatives.

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页码：4947 / 4949

页数：3

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