Hepatitis C virus entry: Molecular biology and clinical implications

被引:93
作者
Barth, Heidi
Liang, T. Jake
Baumert, Thomas F.
机构
[1] Univ Freiburg, Dept Med 2, D-79106 Freiburg, Germany
[2] NIDDKD, Liver Dis Branch, NIH, Bethesda, MD 20892 USA
[3] Univ Strasbourg, INSERM U748, F-67070 Strasbourg, France
关键词
D O I
10.1002/hep.21321
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
With an estimated 170 million infected individuals, hepatitis C virus (HCV) has a major impact on public health. A vaccine protecting against HCV infection is not available, and current antiviral therapies are characterized by limited efficacy, high costs, and substantial side effects. Binding of the virus to the cell surface followed by viral entry is the first step in a cascade of interactions between virus and the target cell that is required for the initiation of infection. Because this step represents a critical determinant of tissue tropism and pathogenesis, it is a major target for host cell responses such as antibody-mediated virus-neutralization-and a promising target for new antiviral therapy. The recent development of novel tissue culture model systems for the study of the first steps of HCV infection has allowed rapid progress in the understanding of the molecular mechanisms of HCV binding and entry. This review summarizes the impact of recently identified viral and host cell factors for HCV attachment and entry. Clinical implications of this important process for the pathogenesis of HCV infection and novel therapeutic interventions are discussed.
引用
收藏
页码:527 / 535
页数:9
相关论文
共 105 条
  • [71] Structural biology of hepatitis C virus
    Penin, F
    Dubuisson, J
    Rey, FA
    Moradpour, D
    Pawlotsky, JM
    [J]. HEPATOLOGY, 2004, 39 (01) : 5 - 19
  • [72] Binding of hepatitis C virus to CD81
    Pileri, P
    Uematsu, Y
    Campagnoli, S
    Galli, G
    Falugi, F
    Petracca, R
    Weiner, AJ
    Houghton, M
    Rosa, D
    Grandi, G
    Abrignani, S
    [J]. SCIENCE, 1998, 282 (5390) : 938 - 941
  • [73] Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR
    Pöhlmann, S
    Zhang, J
    Baribaud, F
    Chen, ZW
    Leslie, G
    Lin, G
    Granelli-Piperno, A
    Dom, RW
    Rice, CM
    McsKeating, JA
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (07) : 4070 - 4080
  • [74] Poveda E, 2005, AIDS REV, V7, P139
  • [75] A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: Cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells
    Rosa, D
    Campagnoli, S
    Moretto, C
    Guenzi, E
    Cousens, L
    Chin, M
    Dong, C
    Weiner, AJ
    Lau, JYN
    Choo, QL
    Chien, D
    Pileri, P
    Houghton, M
    Abrignani, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) : 1759 - 1763
  • [76] Activation of naive B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
    Rosa, D
    Saletti, G
    De Gregorio, E
    Zorat, F
    Comar, C
    D'Oro, U
    Nuti, S
    Houghton, M
    Barnaba, V
    Pozzato, G
    Abrignani, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (51) : 18544 - 18549
  • [77] The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
    Scarselli, E
    Ansuini, H
    Cerino, R
    Roccasecca, RM
    Acali, S
    Filocamo, G
    Traboni, C
    Nicosia, A
    Cortese, R
    Vitelli, A
    [J]. EMBO JOURNAL, 2002, 21 (19) : 5017 - 5025
  • [78] Human monoclonal antibodies that react with the E2 glycoprotein of hepatitis C virus and possess neutralizing activity
    Schofield, DJ
    Bartosch, B
    Shimizu, YK
    Allander, T
    Alter, HJ
    Emerson, SU
    Cosset, FL
    Purcell, RH
    [J]. HEPATOLOGY, 2005, 42 (05) : 1055 - 1062
  • [79] How viruses enter animal cells
    Smith, AE
    Helenius, A
    [J]. SCIENCE, 2004, 304 (5668) : 237 - 242
  • [80] Inhibition of hepatitis c virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C
    Steinmann, D
    Barth, H
    Gissler, B
    Schürmann, P
    Adah, MI
    Gerlach, JT
    Pape, GR
    Depla, E
    Jacobs, D
    Maertens, G
    Patel, AH
    Inchauspé, G
    Liang, TJ
    Blum, HE
    Baumert, TF
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (17) : 9030 - 9040