Replication forks, chromatin loops and dormant replication origins

被引：14

作者：

Blow, J. Julian ^{[1
]}

Ge, Xin Quan ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

来源：

GENOME BIOLOGY | 2008年 / 9卷 / 12期

关键词：

D O I：

10.1186/gb-2008-9-12-244

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.

引用

收藏

页数：4

相关论文

共 25 条

[1] Functional interactions of DNA topoisomerases with a human replication origin [J].

Abdurashidova, Gulnara ;

Radulescu, Sorina ;

Sandoval, Oscar ;

Zahariev, Sotir ;

Danailov, Miltcho B. ;

Demidovich, Alexander ;

Santamaria, Laura ;

Biamonti, Giuseppe ;

Riva, Silvano ;

Falaschi, Arturo .

EMBO JOURNAL, 2007, 26 (04) :998-1009

[2] Dynamics of DNA replication in mammalian somatic cells: Nucleotide pool modulates origin choice and interorigin spacing [J].

Anglana, M ;

Apiou, F ;

Bensimon, A ;

Debatisse, M .

CELL, 2003, 114 (03) :385-394

[3] Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells [J].

Arias, Emily E. ;

Walter, Johannes C. .

GENES & DEVELOPMENT, 2007, 21 (05) :497-518

[4] Heterogeneity of eukaryotic replicons, replicon clusters, and replication foci [J].

Berezney, R ;

Dubey, DD ;

Huberman, JA .

CHROMOSOMA, 2000, 108 (08) :471-484

[5] Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation [J].

Bermejo, Rodrigo ;

Doksani, Ylli ;

Capra, Thelma ;

Katou, Yuki-Mori ;

Tanaka, Hirokazu ;

Shirahige, Katsuhiko ;

Foiani, Marco .

GENES & DEVELOPMENT, 2007, 21 (15) :1921-1936

[6] Replication licensing and cancer - a fatal entanglement? [J].

Blow, J. Julian ;

Gillespie, Peter J. .

NATURE REVIEWS CANCER, 2008, 8 (10) :799-806

[7] Preventing re-replication of chromosomal DNA [J].

Blow, JJ ;

Dutta, A .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (06) :476-486

[8] A RELATIONSHIP BETWEEN REPLICON SIZE AND SUPERCOILED LOOP DOMAINS IN THE EUKARYOTIC GENOME [J].

BUONGIORNONARDELLI, M ;

MICHELI, G ;

CARRI, MT ;

MARILLEY, M .

NATURE, 1982, 298 (5869) :100-102

[9] Replication fork movement sets chromatin loop size and origin choice in mammalian cells [J].

Courbet, Sylvain ;

Gay, Sophie ;

Arnoult, Nausica ;

Wronka, Gerd ;

Anglana, Mauro ;

Brison, Olivier ;

Debatisse, Michelle .

NATURE, 2008, 455 (7212) :557-560

[10] Spatial organization of large-scale chromatin domains in the nucleus: A magnified view of single chromosome territories [J].

Ferreira, J ;

Paolella, G ;

Ramos, C ;

Lamond, AI .

JOURNAL OF CELL BIOLOGY, 1997, 139 (07) :1597-1610