Aminoborohydrides.: 11.: Facile reduction of N-alkyl lactams to the corresponding amines using lithium aminoborohydrides

被引：41

作者：

Flaniken, JM ^{[1
]}

Collins, CJ ^{[1
]}

Lanz, M ^{[1
]}

Singaram, B ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 05期

关键词：

D O I：

10.1021/ol990145e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Various five and six membered N-alkyl lactams were reduced to the corresponding cyclic amines using lithium N,N-dialkylaminoborohydrides (LAB), Most of the reductions were essentially complete after refluxing in THF for 2 h, The cyclic amine products were easily isolated after an aqueous workup in very good to excellent yields. It is possible to selectively reduce most functional groups, such as esters, in the presence of a lactam using LAB reagents.

引用

页码：799 / 801

页数：3

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