Studies on novel synthetic methodologies, part 35.: Iodine catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones:: A simple and efficient procedure for the Biginelli reaction

被引：100

作者：

Srinivas, KVNS ^{[1
]}

Das, B ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2004年 / 13期

关键词：

iodine; aldehydes; 1,3-dicarbonyl compounds; urea; thiourea; one-pot condensation; dihydropyrimidin-ones and thiones; Biginelli reaction;

D O I：

10.1055/s-2004-829170

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iodine efficiently catalyzes the Biginelli reaction. This procedure involves a one-pot three-component cyclocondensation of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or thiones in high yields.

引用

页码：2091 / 2093

页数：3

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