Regenerative Medicine: Does Erythropoietin have a Role?

被引：13

作者：

Buemi, Michele ^{[1
]}

Lacquaniti, Antonio ^{[1
]}

Maricchiolo, Giulia ^{[2
]}

Bolignano, Davide ^{[1
]}

Campo, Susanna ^{[1
]}

Cernaro, Valeria ^{[1
]}

Sturiale, Alessio ^{[1
]}

Grasso, Giovanni ^{[1
]}

Buemi, Antoine ^{[1
]}

Allegra, Alessandro ^{[1
]}

Donato, Valentina ^{[1
]}

Genovese, Lucrezia ^{[2
]}

机构：

[1] Univ Messina, Dept Internal Med, Chair Nephrol, I-98100 Messina, Italy

[2] Ist Sperimentale Talassog, Sez Messina, CNR, IAMC, Messina, Italy

来源：

CURRENT PHARMACEUTICAL DESIGN | 2009年 / 15卷 / 17期

关键词：

Regenerative medicine; erythropoietin; angiogenesis; ERYTHROPOIETIN/ERYTHROPOIETIN-RECEPTOR SYSTEM; ENDOTHELIAL-CELLS; STEM-CELL; ANGIOGENESIS; THERAPY; TRANSITION; EXPRESSION; KIDNEY; MODEL; TREAT;

D O I：

10.2174/138161209788453194

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Regenerative Medicine, a recent new medical domain, aims to develop new therapies through the stimulation of natural regenerative processes also in human beings. In this field, Erythropoietin (EPO) represents a significant subject of research. Several studies allow the assertion that EPO, in different concentrations, has protective effects mainly on the central nervous system, cardiovascular system and renal tissue. This action is carried out through one of few regenerative activities of human beings: angiogenesis. This mechanism, which involves endothelial stem cells and VEGF ( Vascular Endothelial Growth Factor), has been experimentally demonstrated with Recombinant human erythropoietin (rHuEPO) and Darbepoetin, a long-acting EPO derivate. Furthermore, the demonstration of a cardiac production of EPO in Fugu rubripes and in Zebrafish has led cardiologists to "discover" Erythropoietin, postulating a hypothetical role in treatment of cardiovascular disease for this hormone. This is some of the experimental evidence which demonstrates that EPO can be in reason considered an important element of research of Regenerative Medicine and put in the network of drugs able to regenerate tissues and organs.

引用

页码：2026 / 2036

页数：11

共 72 条

[61] Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine [J].

Stoick-Cooper, Cristi L. ;

Moon, Randall T. ;

Weidinger, Gilbert .

GENES & DEVELOPMENT, 2007, 21 (11) :1292-1315

[62] Experimental models of acute renal failure and erythropoietin:: What evidence of a direct effect? [J].

Sturiale, Alessio ;

Campo, Susanna ;

Crasci, Eleonora ;

Aloisi, Carmela ;

Buemi, Michele .

RENAL FAILURE, 2007, 29 (03) :379-386

[63]

TAKAGI H, 2007, DIABETES RES CLIN PR

[64] VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis [J].

Tam, Betty Y. Y. ;

Wei, Kevin ;

Rudge, John S. ;

Hoffman, Jana ;

Holash, Joceyln ;

Park, Sang-ki ;

Yuan, Jenny ;

Hefner, Colleen ;

Chartier, Cecile ;

Lee, Jeng-Shin ;

Jiang, Shelly ;

Niyak, Nihar R. ;

Kuypers, Frans A. ;

Ma, Lisa ;

Sundram, Uma ;

Wu, Grace ;

Garcia, Joseph A. ;

Schrier, Stanley L. ;

Maher, Jacquelyn J. ;

Johnson, Randall S. ;

Yancopoulos, George D. ;

Mulligan, Richard C. ;

Kuo, Calvin J. .

NATURE MEDICINE, 2006, 12 (07) :793-800

[65] TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury [J].

Taoufik, Era ;

Petit, Edwige ;

Divoux, Didier ;

Tseveleki, Vivian ;

Mengozzi, Manuela ;

Roberts, Michael L. ;

Valable, Samuel ;

Ghezzi, Pietro ;

Quackenbush, John ;

Brines, Michael ;

Cerami, Anthony ;

Probert, Lesley .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (16) :6185-6190

[66] Complex networks orchestrate epithelial-mesenchymal transitions [J].

Thiery, JP ;

Sleeman, JP .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (02) :131-142

[67]

WANG L, 2008, J CEREB BLOOD FLOW M

[68] Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy [J].

Watanabe, D ;

Suzuma, K ;

Matsui, S ;

Kurimoto, M ;

Kiryu, J ;

Kita, M ;

Suzuma, I ;

Ohashi, H ;

Ojima, T ;

Murakami, T ;

Kobayashi, T ;

Masuda, S ;

Nagao, M ;

Yoshimura, N ;

Takagi, H .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (08) :782-792

[69] ERYTHROPOIETIN AND THE HUMAN KIDNEY - EVIDENCE FOR AN EVOLUTIONARY LINK FROM STUDIES OF SALMO-GAIRDNERI [J].

WICKRAMASINGHE, SN .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 1993, 104 (01) :63-65

[70] Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA [J].

Yamaji, R ;

Okada, T ;

Moriya, M ;

Naito, M ;

Tsuruo, T ;

Miyatake, K ;

Nakano, Y .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 239 (02) :494-500

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