Improved method for the synthesis of 2-methyl-2-aryloxypropanoic acid derivatives

被引：13

作者：

Davis, RD ^{[1
]}

Fitzgerald, RN ^{[1
]}

Guo, JS ^{[1
]}

机构：

[1] GlaxoSmithKline, Chem Dev Synth Chem, Res Triangle Pk, NC 27709 USA

来源：

SYNTHESIS-STUTTGART | 2004年 / 12期

关键词：

2-methyl-2-aryloxypropanoic acid; PPAR agonist; alkylation; fibric acid;

D O I：

10.1055/s-2004-829171

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved method for the formation of 2-methyl-2-aryloxypropanoic acid derivatives, an important class of compounds for the potential treatment of type II diabetes, is reported. This method offers several advantages over the existing chemistry for this transformation.

引用

页码：1959 / 1962

页数：4