Structure of kaurane-type diterpenes from Parinari sprucei and their potential anticancer activity

被引：19

作者：

Braca, A

Armenise, A

Morelli, L

Mendez, J

Mi, QW

Chai, HB

Chai, HB

Swanson, SM

Kinghorn, AD

Kinghorn, AD

De Tommasi, N

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

[2] Univ Pisa, Dipartimento Chim Bioorgan & Biofarm, I-56100 Pisa, Italy

[3] Cent Univ Venezuela, Escuela Quim, Caracas, Venezuela

[4] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60680 USA

来源：

PLANTA MEDICA | 2004年 / 70卷 / 06期

关键词：

Parinari sprucei; chrysobalanaceae; leaves; kaurane diterpenes; cytotoxicity; hollow fiber test;

D O I：

10.1055/s-2004-827155

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Twenty-three kaurane-type diterpenes 1-23, including twenty new natural products 1-20, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chemical analysis. The isolated compounds were tested for their cytotoxic activity towards a panel of cancer cell lines. Compounds 9 and 10 showed activity against all cell lines with ED50 values in the range of 10-20 mug/mL. The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used.

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收藏

页码：540 / 550

页数：11

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