Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells

被引：94

作者：

Chaouki, Wahid ^{[2
]}

Leger, David Y. ^{[3
]}

Liagre, Bertrand ^{[3
]}

Beneytout, Jean-Louis ^{[3
]}

Hmamouchi, Mohamed ^{[1
]}

机构：

[1] Natl Inst Med & Aromat Plants, Taounate, Morocco

[2] Natl Inst Oncol, Lab Serv, Rabat, Morocco

[3] Fac Pharm, Biochem Lab, F-87025 Limoges, France

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2009年 / 23卷 / 05期

关键词：

anticancer; apoptosis; cell cycle; citral; inducible cyclo-oxgenase-2; MCF-7; cells; PLANT; ANTIBACTERIAL; DIOSGENIN; OIL;

D O I：

10.1111/j.1472-8206.2009.00738.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Many natural components of plants extract are studied for their beneficial effects on health and particularly on carcinogenesis chemoprevention. In this study, we investigated the effect of citral (3,7-dimethyl-2,6-octadienal), a key component of essential oils extracted from several herbal plants, on the proliferation rate, cell cycle distribution, and apoptosis of the human breast cancer cell line MCF-7. The effects of this compound were also tested on cyclo-oxygenase activity. Citral treatment caused inhibition of MCF-7 cell growth (IC50-48 h: 18 x 10(-5) m), with a cycle arrest in G(2)/M phase and apoptosis induction. Moreover, we observed a decrease in prostaglandin E-2 synthesis 48 h after citral treatment. These findings suggest that citral has a potential chemopreventive effect.

引用

页码：549 / 556

页数：8

共 23 条

[11] Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells [J].