Drugs with anticholinergic properties: cognitive and neuropsychiatric side-effects in elderly patients

被引：75

作者：

Cancelli, Iacopo ^{[2
]}

Beltrame, Massimiliano ^{[1
]}

Gigli, Gian Luigi ^{[1
,2
]}

Valente, Mariarosaria ^{[1
,2
]}

机构：

[1] Univ Udine, Sch Med, DPMSC, I-33100 Udine, Italy

[2] Santa Maria Misericordia Univ Hosp, Dept Neurol, Udine, Italy

来源：

NEUROLOGICAL SCIENCES | 2009年 / 30卷 / 02期

关键词：

Elderly patients; Anticholinergic drugs; Side effects; ALZHEIMERS-DISEASE; OLDER-ADULTS; CHOLINERGIC HYPOTHESIS; RISK-FACTORS; DELIRIUM; DEMENTIA; PERFORMANCE; PEOPLE; MEDICATIONS; POPULATION;

D O I：

10.1007/s10072-009-0033-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Drug consumption in older people is usually high and many prescribed medications have unsuspected anticholinergic (ACH) (Table 1) properties. Drug induced ACH side-effects are particularly severe in aging brain and even more in demented patients. This review will focus on the association between ACH drug intake and the risk of developing central nervous system side-effects in elderly people. The threat of developing cognitive impairment, psychosis and delirium will be particularly analyzed.

引用

页码：87 / 92

页数：6

共 59 条

[1] Schizophrenia, sensory gating, and nicotinic receptors [J].

Adler, LE ;

Olincy, A ;

Waldo, M ;

Harris, JG ;

Griffith, J ;

Stevens, K ;

Flach, K ;

Nagamoto, H ;

Bickford, P ;

Leonard, S ;

Freedman, R .

SCHIZOPHRENIA BULLETIN, 1998, 24 (02) :189-202

[2] Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study [J].

Ancelin, ML ;

Artero, S ;

Portet, F ;

Dupuy, AM ;

Touchon, J ;

Ritchie, K .

BMJ-BRITISH MEDICAL JOURNAL, 2006, 332 (7539) :455-458

[3] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[4]

BENTON A, 1965, APPL CLIN EXPT

[5] THE RISK OF ANTICHOLINERGIC TOXICITY IN THE ELDERLY - A STUDY OF PRESCRIBING PRACTICES IN 2 POPULATIONS [J].

BLAZER, DG ;

FEDERSPIEL, CF ;

RAY, WA ;

SCHAFFNER, W .

JOURNALS OF GERONTOLOGY, 1983, 38 (01) :31-35

[6] Long-term cognitive impact of anticholinergic medications in older adults [J].

Bottiggi, Kara A. ;

Salazar, Juan C. ;

Yu, Lei ;

Caban-Holt, Allison M. ;

Ryan, Melody ;

Mendiondo, Marta S. ;

Schmitt, Frederick A. .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2006, 14 (11) :980-984

[7] Drugs with anticholinergic properties as a risk factor for psychosis in patients affected by Alzheimer's disease [J].

Cancelli, I. ;

Valentinis, L. ;

Merlino, G. ;

Valente, M. ;

Gigli, G. L. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 84 (01) :63-68

[8] Factors associated with complex visual hallucinations during antidepressant treatment [J].

Cancelli, I ;

Marcon, G ;

Balestrieri, M .

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2004, 19 (08) :577-584

[9] Drugs With Anticholinergic Properties as a Risk Factor for Cognitive Impairment in Elderly People A Population-Based Study [J].

Cancelli, Iacopo ;

Gigli, Gian Luigi ;

Piani, Antonella ;

Zanchettin, Barbara ;

Janes, Franceso ;

Rinaldi, Adriana ;

Valente, Mariarosaria .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2008, 28 (06) :654-659

[10] Sensory gating deficit assessed by P50/Pb middle latency event related potential in Alzheimer's disease [J].

Cancelli, Iacopo ;

Cadore, Italo Pittaro ;

Merlino, Giovanni ;

Valentinis, Luca ;

Moratti, Ugo ;

Bergonzi, Paolo ;

Gigli, Gian Luigi ;

Valente, Mariarosaria .

JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2006, 23 (05) :421-425

← 1 2 3 4 5 6 →