PtAg nanowires: facile synthesis and their applications as excellent oxygen reduction electrocatalysts for label-free electrochemical immunoassay

被引：30

作者：

Cao, Xia ^{[1
,3
]}

Han, Yu ^{[2
]}

Gao, Caizhen ^{[2
]}

Huang, Xiaomin ^{[2
]}

Xu, Ying ^{[2
]}

Wang, Ning ^{[2
]}

机构：

[1] Capital Med Univ, Sch Biochem & Pharmaceut Sci, Beijing 100069, Peoples R China

[2] Beijing Univ Aeronaut & Astronaut, Sch Chem & Environm, Beijing 100083, Peoples R China

[3] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 100083, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY A | 2013年 / 1卷 / 47期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

FREE DNA DETECTION; ALPHA-FETOPROTEIN; SURFACE; IMMUNOSENSOR; NANOPARTICLES; PERFORMANCE; MOLECULES; BIOMARKER; SENSOR;

D O I：

10.1039/c3ta13071a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Bimetallic PtAg nanowires (PtAgNWs) were synthesized through a water-based mild chemical route for the first time. Due to their high conductivity, large surface area, and synergistic electronic effects of the alloyed Pt-Ag atoms, the obtained catalysts exhibited considerably high oxygen reduction activities. This unique catalytic property along with desired functionalities and surface charge characteristics provide interesting platforms for interfacing signal amplification. A novel label-free electrochemical immunosensor for ultrasensitive detection of alpha-fetoprotein (AFP) was then developed based on bimetallic PtAgNW catalyzed oxygen reduction for signal amplification. Under optimal conditions, the amperometric signal decreases linearly with AFP concentration (0.001-36 ng mL(-1)), resulting in a low limit of detection (0.2 pg mL(-1)). Satisfactory results were demonstrated concerning the application of the novel immunosensor for the detection of AFP in real samples.

引用

页码：14904 / 14909

页数：6

共 34 条

[1]

Polarized Surface-Enhanced Raman Spectroscopy from Molecules Adsorbed in Nano-Gaps Produced by Electromigration in Silver Nanowires [J].