MicroRNAs in Cancer

被引：1456

作者：

Di Leva, Gianpiero ^{[1
]}

Garofalo, Michela ^{[1
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 | 2014年 / 9卷

关键词：

microRNAs; miRs; noncoding RNAs; cancer; TUMOR-SUPPRESSOR MICRORNAS; HUMAN LUNG CANCERS; IN-VIVO; MESENCHYMAL TRANSITION; MESSENGER-RNAS; MIR-200; FAMILY; CELL-PROLIFERATION; DNA METHYLATION; REPRESSORS ZEB1; DOWN-REGULATION;

D O I：

10.1146/annurev-pathol-012513-104715

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration. Thus, miRNAs have been implicated in the regulation of virtually all signaling circuits within a cell, and their dysregulation has been shown to play an essential role in the development and progression of cancer. Here, after a brief description of miRNA genomics, biogenesis, and function, we discuss the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies.

引用

收藏

页码：287 / 314

页数：28

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