The Anti-Cancer Activity of Noscapine: A Review

被引：123

作者：

Mahmoudian, Massoud ^{[1
]}

Rahimi-Moghaddam, Parvaneh ^{[1
]}

机构：

[1] Iran Univ Med Sci, Coll Med, Dept Pharmacol, Razi Inst Drug Res, Tehran, Iran

来源：

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY | 2009年 / 4卷 / 01期

关键词：

Noscapine; antitussive; anti-cancer; anti-mitotic; apoptosis; GUINEA-PIG BRAIN; DEXTROMETHORPHAN BINDING-SITES; OVARIAN-CANCER CELLS; PERTURB MITOSIS; BREAST-CANCER; H-3; NOSCAPINE; APOPTOSIS; PHARMACOKINETICS; TOXICITY; ANALOGS;

D O I：

10.2174/157489209787002524

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally. When the resistance to other anti-cancer drugs such as paclitaxel menifests, noscapine might be effective. Therefore, noscapine and its analogs have great potential as novel anticancer agents.

引用

页码：92 / 97

页数：6

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