Determination of noscapine in human plasma using solid-phase extraction and high-performance liquid chromatography

被引：13

作者：

Chollet, DF

Ruols, C

Arnera, V

机构：

[1] Covance Ctrl. Laboratory Services SA, Bioanalytical Division, Medical Affairs, CH-1217 Meyrinl Geneva

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 701卷 / 01期

关键词：

noscapine;

D O I：

10.1016/S0378-4347(97)00340-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple, reliable high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of noscapine in human plasma. Noscapine and the internal standard, papaverine were quantitatively extracted from plasma onto disposable extraction columns by means of an automated off-line solid-phase extraction system and were separated onto a reversed-phase column. The method was found to be precise and accurate within the range 7.2-270 ng/ml. No endogenous compounds interfered with the assay. (C) 1997 Elsevier Science B.V.

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页码：81 / 85

页数：5

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