Isocyanide-Based Multicomponent Reaction 'without' Isocyanides

被引：22

作者：

El Kaim, Laurent ^{[1
]}

Grimaud, Laurence ^{[1
]}

Schiltz, Aurelie ^{[1
]}

机构：

[1] Ecole Natl Super Tech Avancees, Lab Chim & Procedes, F-75739 Paris 15, France

来源：

SYNLETT | 2009年 / 09期

关键词：

isocyanides; synthesis; alkylation; silver cyanide; Ugi-Smiles; multicomponent reaction; ALKYL-HALIDES; ISONITRILES; EPOXIDES; OXAZOLES; PHASE;

D O I：

10.1055/s-0029-1217184

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting Mixture is directly used in a Ugi-Smiles coupling.

引用

页码：1401 / 1404

页数：4

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