Regulatory T Cells: Key Players in Tolerance and Autoimmunity

被引：21

作者：

Chatila, Talal A. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Immunol Allergy & Rheumatol, Dept Pediat, Los Angeles, CA 90095 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2009年 / 38卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Regulatory T cells; Foxp3; Tolerance; Autoimmunity; IPEX; CD25; TGF-BETA; CUTTING EDGE; IMMUNE DYSREGULATION; TARGET GENES; FOXP3; EXPRESSION; TRANSCRIPTION; ACTIVATION; GENERATION; INDUCTION;

D O I：

10.1016/j.ecl.2009.01.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CD4 + CD25 + regulatory T (TR) lymphocytes are essential to the maintenance of immunologic tolerance in the host. The discovery of Foxp3 as a transcription factor essential to the differentiation of TR ushered in detailed studies of the molecular mechanisms of TR cell development, peripheral homeostasis, and effector functions. In humans, loss of function mutations in genes that regulate T-cell development and function have been associated with TR cell deficiency or dysfunction and syndromes of autoimmunity and immune dysregulation. Augmentation of TR cells by immunotherapy and pharmacologic agents is a promising strategy for the treatment of allergic and autoimmune diseases.

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页码：265 / +

页数：9

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